Pharmacogenetics in Psychiatry: An Update on Clinical Usability
Ron H. N. van Schaik, Daniel J. Müller, Alessandro Serretti, Magnus Ingelman‐Sundberg
Abstract
Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regarding genotyping (SNP analysis/arrays/NGS), structural variant detection (star-alleles/CNVs/hybrid alleles), genotype-to-phenotype translations, cost-effectiveness, and actionability of results (FDA/CPIC/PharmGKB) regarding clinical importance of pre-emptive pharmacogenomic testing for prescription of antidepressants and antipsychotics.
Topics & Concepts
PharmacogeneticsPharmacogenomicsMedicinePsychiatryMedical prescriptionGenetic testingPersonalized medicineGenotypingPharmacologyBioinformaticsGenotypeGeneticsInternal medicineBiologyGenePharmacogenetics and Drug MetabolismPharmaceutical studies and practicesSchizophrenia research and treatment