Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults
Kaleen M. Lavin, Zachary Graham, Jeremy S. McAdam, Samia M. O’Bryan, Devin Drummer, Margaret B. Bell, Christian Kelley, Manoel E. Lixandrão, Brandon Peoples, S. Craig Tuggle, Regina Seay, Kendall Van Keuren‐Jensen, Matthew J. Huentelman, Patrick Pirrotte, Rebecca Reiman, Eric Alsop, Elizabeth Hutchins, Jerry Antone, Anna Bonfitto, Bessie Meechoovet, Joanna Palade, Joshua S. Talboom, Amber Sullivan, Inmaculada Aban, Kalyani Peri, Timothy J. Broderick, Marcas M. Bamman
Abstract
We examined small and long transcriptomics in skeletal muscle and serum-derived extracellular vesicles before and after a single exposure to traditional combined exercise (TRAD) and high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses to TRAD, whereas HITT elicited differential expression of microRNA enriched in brain regions. Follow-up analysis revealed relationships and temporal dynamics across transcript networks, highlighting potential avenues for research into mechanisms of exercise response and adaptation.