The genomics of sporadic and hereditary colorectal cancer
Iannish Sadien, RJ Davies, JMD Wheeler
Abstract
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, with different subtypes characterised by distinct somatic mutational profiles, epigenetic aberrations and transcriptomic signatures. This review summarises our current understanding of the genomic and epigenomic alterations implicated in CRC development and progression. Particular focus is given to how characterisation of CRC genomes is leading to more personalised approaches to diagnosis and treatment.
Topics & Concepts
EpigenomicsColorectal cancerEpigeneticsGenomicsCancerMedicineBioinformaticsTranscriptomeGenomeSomatic cellComputational biologyBiologyGeneticsDNA methylationInternal medicineGeneGene expressionGenetic factors in colorectal cancerColorectal Cancer Treatments and StudiesColorectal Cancer Screening and Detection