Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
Li Shen, Jennifer Dien Bard, Jaclyn A. Biegel, Alexander R. Judkins, Xiaowu Gai
Abstract
Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. This points to the effectiveness of existing travel restriction policies and public health measures in reducing the transmission of SARS-CoV-2.
Topics & Concepts
HaplotypeSAFERTransmission (telecommunications)OutbreakGenomeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiologyCoronavirus disease 2019 (COVID-19)State (computer science)PandemicPublic healthGenetics2019-20 coronavirus outbreakGeographyEvolutionary biologyVirologyDiseaseGenotypeGeneMedicineComputer scienceComputer securityInfectious disease (medical specialty)TelecommunicationsNursingPathologyAlgorithmSARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesSARS-CoV-2 detection and testing