NiH-catalyzed dearomative hydroalkylation of indoles
Kai Liu, Yu-Feng Song, Yang Gao, Jie-Qiong Luo, Yi‐Xia Jia
Abstract
A NiH-catalyzed intermolecular dearomative hydroalkylation of indoles has been developed, which assembles an array of structurally diverse C2-alkylated indolines with moderate to excellent yields. This protocol exhibits good functional group tolerance, allowing for late-stage functionalization of complex drug molecules.
Topics & Concepts
CatalysisIntermolecular forceCombinatorial chemistryAlkylationFunctional groupMoleculeChemistrySurface modificationStereochemistryOrganic chemistryPolymerPhysical chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions