Roeperone A, a new tetraoxygenated xanthone and other compounds from the leaves of <i>Hypericum roeperianum</i> Schimp. (Hypericaceae)
François Damen, James D. Simo Mpetga, Olive Monique F. Demgne, İlhami Çelik, Brice E. N. Wamba, Léon Azefack Tapondjou, Véronique Penlap Beng, Serkan Levent, Victor Kuete, Mathieu Téné
Abstract
led to the isolation of a new tetraoxygenated xanthone along with eleven known compounds including six xanthones, one polyketide, one flavonoid, one ferulic acid derivative and two pentacyclic triterpenoids. Their structures were established on the basis of 1D- and 2D-NMR, UV, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The new xanthone was tested against a panel of eight bacterial strains including six Gram-negative and two Gram-positive bacteria. As results, it exhibited weak antibacterial activity with MIC values ranging from 64 to 128 µg/mL.