Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling
Cong Tang, Xiulei Mo, Qiankun Niu, Alafate Wahafu, Xuan Yang, Min Qui, Andrei A. Ivanov, Yuhong Du, Haian Fu
Topics & Concepts
SuppressorInducerMutantMediatorBiologyFunction (biology)Cell biologyMutationGain of functionSignal transductionGeneCancer researchGeneticsTGF-β signaling in diseasesUbiquitin and proteasome pathwaysCancer-related gene regulation