Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy
Jongsung Hahn, Kyoung Lok Min, Soyoung Kang, Seungwon Yang, Min Soo Park, Jin Wi, Min Jung Chang
Abstract
To the best of our knowledge, this is the first large prospective pharmacokinetic/pharmacodynamic (PK/PD) study of piperacillin-tazobactam in ECMO patients. We used piperacillin-tazobactam plasma concentration data from four different cases (concomitant use of ECMO and CVVHDF, receiving ECMO only, weaned from ECMO and receiving CVVHDF, and weaned from ECMO and not receiving CVVHDF) to provide preliminary insights into the incremental effects of critical illness, ECMO, and CVVHDF on PK.
Topics & Concepts
Piperacillin/tazobactamExtracorporeal membrane oxygenationMedicinePiperacillinDosingConcomitantPharmacokineticsPharmacodynamicsRenal replacement therapyIntensive care medicineTazobactamPopulationAnesthesiaPharmacologyInternal medicineGeneticsBiologyEnvironmental healthPseudomonas aeruginosaBacteriaAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory InfectionsAntibiotic Resistance in Bacteria