The potential therapeutic targets of glutamine metabolism in head and neck squamous cell carcinoma
Shutian Guo, Xinmiao Wang, Yifan Wang, Junqiang Bai, Yi Liu, Zhe Shao
Abstract
Targeting metabolic reprogramming may be an effective strategy to enhance cancer treatment efficacy. Glutamine serves as a vital nutrient for cancer cells. Inhibiting glutamine metabolism has shown promise in preventing tumor growth both in vivo and in vitro through various mechanisms. Therefore, this review collates recent scientific literature concerning the correlation between glutamine metabolism and cancer treatment. Novel treatment modalities based on amino acid transporters, metabolites, and glutaminase are discussed. Moreover, we demonstrate the relationship between glutamine metabolism and tumor proliferation, drug resistance, and the tumor immune microenvironment, offering new perspectives for the clinical treatment of head and neck squamous cell carcinoma, particularly for combined therapies. Identifying innovative approaches for enhancing the efficacy of glutamine-based metabolic therapy is crucial to improving HNSCC treatment. • Metabolism reprogramming is essential for tumor microenvironment. • Glutamine metabolism restriction is effective in inhibiting tumor growth. • Targeting glutamine metabolism can be a potential therapy. • Combined therapy is critical for head and neck squamous cell carcinoma.