GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells
Huina Liu, Xiao Han, Haoqing Yang, Yangyang Cao, Chen Zhang, Juan Du, Shu Diao, Zhipeng Fan
Abstract
: In summary, our findings suggested that GREM1 inhibited ADSCs senescence and osteogenic differentiation and antagonized BMP transcription.
Topics & Concepts
RUNX2Bone morphogenetic protein 2TelomeraseCell biologyGene knockdownAlkaline phosphataseStem cellChemistryCellular differentiationSenescenceDMP1Bone morphogenetic protein 7Bone morphogenetic proteinMolecular biologyBiologyIn vitroGeneBiochemistryEnzymeViral matrix proteinMesenchymal stem cell researchGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence