Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer
Shujian Hu, Wantong Ma, Junyi Wang, Yunhao Ma, Zhongkun Zhou, Rentao Zhang, Kangjia Du, Hao Zhang, Mengze Sun, Xinrong Jiang, Hongyuan Tu, Xiaoliang Tang, Xiaojun Yao, Peng Chen
Topics & Concepts
PI3K/AKT/mTOR pathwayApoptosisProtein kinase BCell cycleChemistryCytotoxicityImidazoleCell growthCell cycle checkpointCancer researchCancer cellIn vitroWestern blotCancerCell culturePharmacologyBiochemistryBiologyMedicineInternal medicineGeneticsGeneCancer therapeutics and mechanismsSynthesis and biological activityQuinazolinone synthesis and applications