Sulfonamide-phosphonate hybrids as new carbonic anhydrase inhibitors: In vitro enzymatic inhibition, molecular modeling, and ADMET prediction
Samira Zareei, Maryam Mohammadi‐Khanaposhtani, Mehdi Adib, Mohammad Mahdavi, Parham Taslımı
Topics & Concepts
ChemistryAcetazolamideCarbonic anhydrasePhosphonateSulfonamideCarbonic anhydrase IIStereochemistryEnzymeADMEActive siteLipinski's rule of fiveLead compoundIn vitroBiochemistryIn silicoAnesthesiaMedicineGeneEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities