Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
Alex H. Y. Chan, Imam Fathoni, Terence C. S. Ho, Kevin J. Saliba, Finian J. Leeper
Abstract
for the unfunctionalized benzoyl ester), nor by overexpressing thiamine pyrophosphokinase in the parasite, making it unlikely to be due to an effect on thiamine transport or metabolism.
Topics & Concepts
ThiamineThiamine pyrophosphateChemistryIC50BiochemistryStereochemistryIn vitroEnzymeCofactorAlcoholism and Thiamine DeficiencyBiochemical Acid Research StudiesMetabolism and Genetic Disorders