In-Membrane Nanostructuring of Cationic Amphiphiles Affects Their Antimicrobial Efficacy and Cytotoxicity: A Comparison Study between a De Novo Antimicrobial Lipopeptide and Traditional Biocides
Ke Fa, Huayang Liu, Haoning Gong, L. Zhang, Mingrui Liao, Xuzhi Hu, Daniela Ciumac, Peixun Li, John R. P. Webster, Jordan T. Petkov, Robert K. Thomas, Jian R. Lu
Abstract
TAB binding to the model membranes showed low selectivity, and its high cytotoxicity could be attributed to both membrane lysis and chemical toxicity. This work demonstrates the advantages of the lipopeptides and their potential for further development toward clinical application.
Topics & Concepts
LipopeptideCytotoxicityAntimicrobialMembraneBiocideAntimicrobial peptidesCationic polymerizationZeta potentialChemistryCytolysinAmphiphileLysisBiophysicsCombinatorial chemistryBiochemistryBacteriaBiologyMaterials scienceIn vitroNanotechnologyOrganic chemistryNanoparticleGenePolymerCopolymerVirulenceGeneticsAntimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsLipid Membrane Structure and Behavior