Facile construction of the all-bridge-position-functionalized 2,4,6,8-tetraazaadamantane skeleton and conversion of its <i>N</i>-functionalities
Rongbin Cai, Qi Zhou, Tianjiao Hou, Bing Li, Yunzhi Liu, Huan Li, Yuan Gao, Longyi Zhu, Jun Luo
Abstract
An unusual protocol of a “one-pot” three-step strategy to build the 2,4,6,8-tetraazaadamantane skeleton was developed. 17 products were obtained in 19–46% yields, and the N -benzyl groups were transferred to nitroso, acetyl, benzoyl and nitro groups.
Topics & Concepts
ChemistrySkeleton (computer programming)NitroNitrosoBridge (graph theory)Combinatorial chemistryOrganic chemistrySurgeryAlkylProgramming languageMedicineComputer scienceMetal-Catalyzed Oxygenation MechanismsMagnetism in coordination complexesLanthanide and Transition Metal Complexes