A biophotonic device based on a conjugated polymer and a macrophage-laden hydrogel for triggering immunotherapy
Zhiwen Yang, Qi Shen, Longjiang Xing, Xuancheng Fu, Zhipeng Qiu, Hongping Xiang, Yiming Huang, Fengting Lv, Haotian Bai, Yanping Huo, Shu Wang
Abstract
A biophotonic device is fabricated for employing a flexible OLED to excite conjugated polymer PPV in a macrophage (M 0 )-laden 3D printed hydrogel, resulting in the generation of ROS and subsequent M 1 macrophage polarization for tumor immunotherapy.
Topics & Concepts
Materials scienceConjugated systemImmunotherapyMacrophagePolymerMacrophage polarizationNanotechnologyBiomedical engineeringMedicineChemistryComposite materialImmunologyImmune systemIn vitroBiochemistryNanoplatforms for cancer theranosticsOcular Surface and Contact LensMolecular Communication and Nanonetworks