Survival and Glycemic Control in Patients With co-existing Squamous Cell Carcinoma and Diabetes Mellitus
Sophia A. Ederaine, Johanny Lopez Dominguez, Jamison A. Harvey, Aaron R. Mangold, Curtiss B. Cook, Heidi Kosiorek, Matthew Buras, Kyle Coppola, Nina J. Karlin
Abstract
Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A1c (HbA1c) and glucose level during the year following cancer diagnosis were compared using mixed models. Results: HbA1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.