MicroRNA-181 regulates the development of Ossification of Posterior longitudinal ligament via Epigenetic Modulation by targeting PBX1
Ning Liu, Zicheng Zhang, Li Li, Xiaolong Shen, Baifeng Sun, Ruizhe Wang, Huajian Zhong, Qianghui Shi, Leixin Wei, Yizhi Zhang, Yue Wang, Chen Xu, Yang Liu, Wen Yuan
Abstract
. Our work is the first to demonstrate that microRNA perturbation could modulate the development of OPLL through epigenetic regulation.
Topics & Concepts
Heterotopic ossificationOssificationAntagomirChromatin immunoprecipitationPosterior longitudinal ligamentAlkaline phosphatasemicroRNAWestern blotPathologyALIZARIN REDReal-time polymerase chain reactionBiologyMolecular biologyStainingMedicineGene expressionAnatomyGenePromoterGeneticsBiochemistryEnzymeCervical and Thoracic MyelopathyEndometriosis Research and TreatmentHeterotopic Ossification and Related Conditions