A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia
Biyun Zheng, Kyung-Pil Ko, Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn‐Sang Jung, Christopher Cervantes, Jae‐Il Park
Abstract
expression in EOs induced the development of esophageal squamous neoplasia, an early lesion of ESCC. Here we propose the new formula for EO culture with minimum components and the organoid model recapitulating ESCC initiation, laying the foundation for ESCC research and drug discovery.
Topics & Concepts
OrganoidEsophageal squamous cell carcinomaCell cultureBiologyTranscriptomeCancer researchCellCell biologyPathologyMedicineCarcinomaGeneGene expressionBiochemistryGeneticsCancer Cells and MetastasisRenal and related cancersCancer Genomics and Diagnostics