Respiratory Syncytial Virus Activates Rab5a To Suppress IRF1-Dependent Lambda Interferon Production, Subverting the Antiviral Defense of Airway Epithelial Cells
Shi Mo, Wei Tang, Jun Xie, Sisi Chen, Ren Luo, Na Zang, Xiaohong Xie, Yu Deng, Leiqiong Gao, Enmei Liu
Abstract
This study highlights the important role of Rab5a in RSV infection, such that its depletion inhibits RSV infection by stimulating the endogenous respiratory epithelial antiviral immunity and attenuates inflammation of the airway, which suggests that Rab5a is a powerful potential target for novel therapeutics against RSV infection.
Topics & Concepts
BiologyIRF1VirologyInterferonVirusRespiratory systemLambdaInterferon gammaImmunologyCytokineGeneGene expressionGeneticsAnatomyOpticsPhysicsRespiratory viral infections researchViral Infections and VectorsViral gastroenteritis research and epidemiology