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Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo

Huajian Zhu, Wenjian Zhu, Yang Liu, Tian Gao, Jingjie Zhu, Yuchen Tan, Han Hu, Wenhao Liang, Lingyue Zhao, Jian Chen, Jian Chen, Zheying Zhu, Jichao Chen, Jichao Chen, Jinyi Xu, Shengtao Xu

2023European Journal of Medicinal Chemistry18 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryIn vivoTubulinIn vitroApoptosisCell cultureIC50Cell cycle checkpointCell growthCell cycleCancer researchMicrotubulePharmacologyBiochemistryCell biologyBiologyBiotechnologyGeneticsHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsSynthetic Organic Chemistry Methods
Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo | Litcius