Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism
E. E. Vaiman, N. А. Shnayder, Aiperi K. Khasanova, Anna Strelnik, Arseny Gayduk, Mustafa Al-Zamil, М. Р. Сапронова, Н. Г. Жукова, Daria Smirnova, Р. Ф. Насырова
Abstract
Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.
Topics & Concepts
AdenosinergicParkinsonismNeuroscienceNeurotransmitterEndocannabinoid systemDopaminergicCholinergicDopamineNeurotransmitter receptorDopaminergic pathwaysAntipsychoticSchizophrenia (object-oriented programming)Dopamine receptorMedicinePharmacologyBiologyReceptorInternal medicineCentral nervous systemPsychiatryDiseaseAgonistAdenosine receptorNeuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior