Anticancer activity of new triazolopyrimidine linked coumarin and quinolone hybrids: Synthesis, molecular modeling, TrkA, PI3K/AKT and EGFR inhibition
Rasha Z. Batran, Eman Y. Ahmed, Eman S. Nossier, Hanem M. Awad, Nehad A. Abdel Latif
Topics & Concepts
ChemistryCoumarinCytotoxicityProtein kinase BPI3K/AKT/mTOR pathwayTrk receptorDocking (animal)Cancer cellMolecular modelApoptosisBiochemistryIn silicoCell cycle checkpointCell cycleIn vitroCancerReceptorGeneOrganic chemistryInternal medicineNeurotrophinNursingMedicineSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Characterization of Heterocyclic Compounds