TRPC1 participates in the HSV-1 infection process by facilitating viral entry
Dongxu He, AiQin Mao, Youran Li, SiuCheung Tam, Yong‐Tang Zheng, Xiaoqiang Yao, Lutz Birnbaumer, Indu S. Ambudkar, Xin Ma
Abstract
mice. There was a strong correlation between HSV-1 infection and plasma membrane localization of TRPC1 in epithelial cells within oral lesions in buccal biopsies from HSV-1-infected patients. Together, our findings demonstrate a critical role for TRPC1 in HSV-1 infection and suggest the channel as a potential target for anti-HSV therapy.
Topics & Concepts
TRPC1Viral entryProcess (computing)VirologyViral infectionChannel (broadcasting)VirusComputational biologyComputer scienceCell biologyBiologyReceptorViral replicationGeneticsIon channelComputer networkOperating systemIon Channels and ReceptorsFood Allergy and Anaphylaxis ResearchToxin Mechanisms and Immunotoxins