Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression
James W. Opzoomer, Joanne E. Anstee, Isaac Dean, Emily J. Hill, Ihssane Bouybayoune, Jonathan Caron, Tamara Muliaditan, Peter M. Gordon, Dominika Sosnowska, Rosamond Nuamah, Sarah E. Pinder, Tony Ng, Francesco Dazzi, Shahram Kordasti, David R. Withers, Toby Lawrence, James N. Arnold
Abstract
TAMs in orchestrating a selective platelet-derived growth factor–CC–dependent expansion of the perivascular mesenchymal population, creating a proangiogenic niche. This study highlights the inter-reliance of the immune and nonimmune stromal network that supports cancer progression and provides therapeutic opportunities for tackling the disease.
Topics & Concepts
NicheCancerBiologyNeuroscienceCancer researchMedicineEcologyGeneticsImmune cells in cancerExtracellular vesicles in diseaseAngiogenesis and VEGF in Cancer