Wnt5a regulates Ameloblastoma Cell Migration by modulating Mitochondrial and Cytoskeletal Dynamics
Xue Qiao, Xing Niu, Jun-Xiu Shi, Lijie Chen, Xiaobin Wang, Jinwen Liu, Li Zhu, Ming Zhong
Abstract
Together, these results suggest that Wnt5a plays mitochondria and cytoskeleton specific roles in regulating the development of human AB, with its down-regulation leading to impaired tumor development, thus highlighting Wnt5a or Coro1A as potentially viable therapeutic targets for the treatment of AB.
Topics & Concepts
WNT5ACell biologyCytoskeletonMitochondrionOrganelleWestern blotCell migrationBiologyCellSignal transductionWnt signaling pathwayBiochemistryGeneOral and Maxillofacial PathologyCancer Cells and MetastasisTissue Engineering and Regenerative Medicine