MicroRNA-29a-3p delivery via exosomes derived from engineered human mesenchymal stem cells exerts tumour suppressive effects by inhibiting migration and vasculogenic mimicry in glioma
Zongpu Zhang, Xing Guo, Xiaofan Guo, Rui Yu, Mingyu Qian, Shaobo Wang, Xiao Gao, Wei Qiu, Qindong Guo, Jianye Xu, Zihang Chen, Huizhi Wang, Yanhua Qi, Rongrong Zhao, Hao Xue, Gang Li
Abstract
. Overall, the present study demonstrates that MSCs can be used to produce miR-29a-3p-overexpressing exosomes, which have great potential for anti-VM therapy and may act as supplements to anti-angiogenetic therapy in the clinic.
Topics & Concepts
Vasculogenic mimicryMicrovesiclesMesenchymal stem cellGliomaAngiogenesisCancer researchmicroRNAExosomeBiologyStem cellCell biologyCell migrationImmunologyIn vitroChemistryCancerMetastasisBiochemistryGeneticsGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases