The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
Varun S. Venkatesh, Mathis Grossmann, Jeffrey D. Zajac, Rachel A. Davey
Abstract
Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males. Here, we summarize recent evidence derived from clinical trials and studies in preclinical animal models regarding the role of androgen receptor (AR) signaling in the pathophysiology of males with obesity. We also discuss therapeutic strategies targeting the AR for the treatment of obesity and their limitations and provide insight into the future research necessary to advance this field.
Topics & Concepts
Androgen receptorObesityMedicineBioinformaticsClinical trialAndrogenTestosterone (patch)PathogenesisPathophysiologyInternal medicineEndocrinologyReceptorBiologyHormoneProstate cancerCancerHormonal and reproductive studiesPharmacology and Obesity TreatmentGrowth Hormone and Insulin-like Growth Factors