Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties
Huajian Zhu, Lixue Lu, Wenjian Zhu, Yuchen Tan, Yiping Duan, Jie Liu, Wen‐Cai Ye, Zheying Zhu, Jinyi Xu, Shengtao Xu
Topics & Concepts
ChemistryProdrugApoptosisIn vivoCell cycleIntracellularPharmacologyA549 cellWestern blotBiochemistryStereochemistryBiologyBiotechnologyGeneBioactive Compounds and Antitumor AgentsCancer therapeutics and mechanismsGenomics, phytochemicals, and oxidative stress