Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals – a randomized intervention trial
Karin B. Michels, Alexandra M. Binder
Abstract
-value = 0.03). No notable changes in the methylome resulting from the folic acid supplementation emerged. In this population with adequate folate levels derived from diet, an increase in RBC folate had a modest impact on the epigenetic clock predicting chronologic age.
Topics & Concepts
DNA methylationEpigeneticsMethylationBiologyPopulationGeneticsBioinformaticsDNAGeneMedicineGene expressionEnvironmental healthEpigenetics and DNA MethylationFolate and B Vitamins ResearchGenetic Syndromes and Imprinting