Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors
Yuru Liang, Mao Zhang, Pengfei Zhou, Mingming Liu, Jianqi Li, Yang Wang
Topics & Concepts
ChemistryIn vitroApoptosisTubulinSubstituentStereochemistryArylIntracellularCell cycleMicrotubulePharmacologyBiochemistryCell biologyOrganic chemistryBiologyAlkylSynthesis of β-Lactam CompoundsPhytochemical compounds biological activitiesMicrobial Natural Products and Biosynthesis