Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues <i>via</i> combinatorial biosynthesis
Xinyu Li, Jian‐Ming Lv, Zhiqin Cao, Gao‐Qian Wang, Fu-Long Lin, Guo‐Dong Chen, Sheng-Ying Qin, Dan Hu, Hao Gao, Xin‐Sheng Yao
Abstract
Characterization of polytolypin biosynthesis and generation of new polytolypin analogues via combinational expression of three new fernane cyclases with tailoring enzymes.
Topics & Concepts
ChemistryAntifungalBiosynthesisTriterpenoidTerpeneStereochemistryCombinatorial chemistryBiochemistryMicrobiologyGeneBiologyNatural product bioactivities and synthesisPlant biochemistry and biosynthesisPhytochemical compounds biological activities