Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis
Mei Wang, Yanwen Xu, Yuncong Zhang, Yuhan Chen, Gang Chang, Geng An, Xinyan Yang, Caihong Zheng, Jiexiang Zhao, Zhaoting Liu, Dazhuang Wang, Kai Miao, Shuan Rao, Meng Dai, Dong Wang, Xiaoyang Zhao
Abstract
Our study provides comprehensive insights into the global transcriptional signatures of autophagy-related genes and confirms the importance of autophagy homeostasis in SSC maintenance and normal spermatogenesis, opening new avenues for further dissecting the significance of the autophagy regulatory network in spermatogenesis as well as male infertility.
Topics & Concepts
AutophagyBiologyGene knockdownCell biologySpermatogenesisAzoospermiaGerm cellGeneTFEBGeneticsInfertilityEndocrinologyApoptosisPregnancySperm and Testicular FunctionEpigenetics and DNA MethylationMicroRNA in disease regulation