Visible-Light-Driven Multicomponent Diamination and Oxyamination of Alkene
Mengping He, Chengcheng Shi, Mengqi Luo, Chao Yang, Lin Guo, Yating Zhao, Wujiong Xia
Abstract
Herein, we describe an effective method for the synthesis of 2-alkoxyamides and 1,2-diamines through visible-light-mediated difunctionalization of alkenes. N -Aminopyridinium salts were employed as appropriate precursors to generate key amidyl radical intermediates via a photoinduced single-electron transfer (SET) process. The amidyl radicals would react with alkenes, followed by oxidation and nucleophilic addition. Excellent functional group tolerance and good yields demonstrate the synthetic potential of this transformation.
Topics & Concepts
ChemistryAlkeneRadicalNucleophileCombinatorial chemistryPhotochemistryFunctional groupPhotoinduced electron transferVisible spectrumElectron transferOrganic chemistryCatalysisOptoelectronicsPolymerPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques