Gαi-biased apelin analog protects against isoproterenol-induced myocardial dysfunction in rats
David Coquerel, Eugénie Delile, L Dumont, Frédéric Chagnon, Alexandre Murza, Xavier Sainsily, Dany Salvail, Philippe Sarret, Éric Marsault, Mannix Auger‐Messier, Olivier Lesur
Abstract
By using more potent Gαi-biased APJ agonists that strongly inhibit cAMP production, these data point to the negative inotropic effect of APJ-mediated Gαi signaling in the heart and highlight the potential protective impact of APJ-dependent Gαi signaling in cardiovascular diseases associated with left ventricular hypertrophy.
Topics & Concepts
InotropeApelinMedicineInternal medicineMyocardial hypertrophyEndocrinologyPharmacologyMuscle hypertrophyReceptorCardiologyApelin-related biomedical researchNuclear Receptors and SignalingCardiovascular, Neuropeptides, and Oxidative Stress Research