Exploring improved strategies for therapeutic studies and biological activities of novel zinc and indium phthalocyanines
Kevser Celep, Göknur Yaşa Atmaca, Pelin Demir Aydoğmuş, Kumsal Eroğlu, Ömer Tahir Günkara, Gülay Giray, Gülşah Tollu, Sadin Özdemir, Ali Erdoğmuş
Abstract
values of 0.91 and 0.94, respectively. Furthermore, the evaluation for biological properties revealed that both D3 and D4 exhibit significant antidiabetic properties, DPPH radical scavenging activity, DNA cleavage, antimicrobial activity, biofilm inhibition, and microbial cell viability impacts, both with and without photodynamic therapy. Notably, D3 and D4 achieved antimicrobial cell viability inhibition rates of 84.67 ± 4.67% and 98.32 ± 5.96%, respectively, showcasing their effectiveness in photodynamic antimicrobial therapy. Overall, the study highlights the potential of these phthalocyanine complexes as advanced photosensitizers, with strong singlet oxygen generation and promising biological activities, paving the way for future therapeutic applications.