Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway
Chengyu Mao, Dongjiu Li, En Zhou, Junfeng Zhang, Changqian Wang, Chao Xue
Abstract
reversed the effects of nicotine on macrophage invasion and vascular injury. Nicotine also induced pyroptotic macrophages that contributed to the apoptotic death of endothelial cells. These findings suggest that nicotine accelerates atherosclerosis in part by promoting macrophage pyroptosis and endothelial damage. Therefore, targeting the TXNIP/NLRP3-mediated pyroptotic pathway in macrophages may ameliorate nicotine-induced endothelial damage.
Topics & Concepts
PyroptosisTXNIPInflammasomeNicotineMedicineMacrophageImmunologyInflammationCancer researchPharmacologyChemistryOxidative stressEndocrinologyInternal medicineIn vitroBiochemistryThioredoxinInflammasome and immune disordersAtherosclerosis and Cardiovascular DiseasesIL-33, ST2, and ILC Pathways