Dapagliflozin attenuates cholesterol overloading-induced injury in mice hepatocytes with type 2 diabetes mellitus (T2DM) via eliminating oxidative damages
Yang Liu, Dan Liu, Hongqin Yan, Kaixia Chen
Abstract
. Furthermore, the potential underlying mechanisms were uncovered, and our data suggested that Dapagliflozin activated the anti-oxidant Nrf2/HO-1 pathway in mice hepatocytes, and silencing of Nrf2 abrogated the protective effects of Dapagliflozin on cholesterol-overloaded hepatocytes. Collectively, we concluded that Dapagliflozin recovered cholesterol metabolism functions in T2DM mice liver via activating the anti-oxidant Nrf2/HO-1 pathway, and our data supported that Dapagliflozin was a potential therapeutic drug to eliminate cholesterol-induced cytotoxicity during T2DM pathogenesis.
Topics & Concepts
DapagliflozinBiologyCholesterolHepatocyteIn vivoType 2 Diabetes MellitusPharmacologyEndocrinologyInternal medicineDiabetes mellitusBiochemistryIn vitroMedicineBiotechnologyDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerChronic Kidney Disease and Diabetes