Visible-light induced C(sp<sup>3</sup>)–H arylation of glycine derivatives by cerium catalysis
Shutao Wang, Yanjie Ye, Hailong Shen, Jiyu Liu, Zhao Liu, Zhigen Jiang, Junqiang Lei, Yuan Zhang
Abstract
A Ce(III)-catalyzed, visible-light induced aerobic oxidative dehydrogenative coupling reaction between glycine derivatives and electron-rich arenes is disclosed. The protocol proceeds efficiently under mild conditions, providing an efficient method for the rapid synthesis of α-arylglycine derivatives without the need for an external photosensitizer and additional oxidant. Moreover, this protocol could be performed on a 5 mmol scale, without obvious reduction of the efficiency.
Topics & Concepts
ChemistryCeriumGlycineCatalysisPhotosensitizerVisible spectrumPhotochemistryCombinatorial chemistryOxidative phosphorylationReaction conditionsMedicinal chemistryOrganic chemistryBiochemistryAmino acidOptoelectronicsPhysicsRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques