Huntington disease: somatic expansion, pathobiology and therapeutics
Jasmine Donaldson, Davina Hensman Moss, Marc Ciosi, Karen Usdin, Gabriel Balmus, Darren G. Monckton, Sarah J. Tabrizi
Topics & Concepts
HuntingtinTrinucleotide repeat expansionSomatic cellDiseaseHuntington's diseasePolyglutamine tractMedicineHuntingtin ProteinMechanism (biology)NeurodegenerationPhenotypeMutationPathologicalPoint mutationGeneticsBioinformaticsTransgeneBiologyGeneCognitive declineNeuroscienceClinical trialDNA repairClinical phenotypeDNA sequencingDNA damageAmyotrophic lateral sclerosisDNAGenetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders