Oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin promotes the malignant phenotype of glioma
Yu Zeng, Tianshi Que, Jie Lin, Zhengming Zhan, Anqi Xu, Zhiyong Wu, Cheng Xie, Jie Luo, Shengfeng Ding, Hao Long, Xian Zhang, Ye Song
Abstract
. Furthermore, interaction between cytoplasmic HMGA1 and vimentin was observed, and vimentin inhibition could abolish increased migration and invasion induced by HMGA1 overexpression. Both HMGA1 and vimentin were associated with an unfavorable prognosis in glioma. Additionally, upregulated HMGA1 and vimentin were found in isocitrate dehydrogenase (IDH) wild-type and 1p/19q non-codeletion diffusely infiltrating glioma. In conclusion, we identified an oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin that promotes both migration and invasion in glioma.
Topics & Concepts
VimentinGliomaCancer researchDownregulation and upregulationHomeoboxmicroRNABiologyZinc fingerChemistryTranscription factorImmunologyImmunohistochemistryGeneticsGeneMicroRNA in disease regulationRNA Research and SplicingCircular RNAs in diseases