A new depsidone derivative from mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-A9
Lili Hao, Dexiong Zhou, Xiaoya Qin, Wenxiu Zhang, Rui‐Yun Yang, Jun Li, Xishan Huang
Abstract
A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2–4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds 1–4 were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound 1 significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC50 value of 8.22 µM.
Topics & Concepts
MangroveFungusDerivative (finance)IC50ChemistryNitric oxideAspergillusStereochemistryBiochemistryBiologyMicrobiologyBotanyOrganic chemistryIn vitroEcologyFinancial economicsEconomicsMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsMarine Sponges and Natural Products