A multifunctional 3D dressing unit based on the core–shell hydrogel microfiber for diabetic foot wound healing
Qiwei Huang, Tingbin Wu, Lihuan Wang, Jichang Zhu, Yongshi Guo, Xi Yu, Long Fan, John H. Xin, Hui Yu
Abstract
experiments with type 2 diabetic rats were performed over a 14-day period to compare the performance of the multifunctional 3D dressing with a gauze control; the multifunctional 3D dressing reduced inflammation, effectively increased the post-healing thickness of granulation tissue, and promoted the formation of blood vessels, hair follicles, and highly oriented collagen fiber networks. Therefore, the proposed multifunctional dressing is expected to be suitable for clinical applications for healing diabetic foot wounds.
Topics & Concepts
MicrofiberDiabetic footWound healingCore (optical fiber)Shell (structure)ChemistryBiomedical engineeringMaterials scienceSurgeryComposite materialMedicineDiabetes mellitusEndocrinologyWound Healing and TreatmentsDiabetic Foot Ulcer Assessment and Management3D Printing in Biomedical Research