Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
Priya Prakash, Krupal P. Jethava, Nils Korte, Pablo Izquierdo, Emilia Favuzzi, Indigo V.L. Rose, Kevin A. Guttenplan, Palak Manchanda, Sayan Deb Dutta, Jean‐Christophe Rochet, Gord Fishell, Shane A. Liddelow, David Attwell, Gaurav Chopra
Abstract
can be used to investigate the phagocytic mechanisms responsible for removing Aβ from the extracellular space, and thus could become a useful tool to study Aβ clearance at different stages of AD.
Topics & Concepts
PhagocytosisMicrogliaCellCell biologyFunction (biology)Amyloid (mycology)Brain CellNeuroscienceCortex (anatomy)BiologyChemistryPathologyImmunologyMedicineBiochemistryInflammationAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsAdvanced Glycation End Products research