Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
Ebrahim Abbasi, Seyed Alireza Vafaei, Nima Naseri, Ali Darini, Masoumeh Taheri Azandaryani, Farhad Kian Ara, Fatemeh Mirzaei
Abstract
BACKGROUND AND AIMS: )-induced liver fibrosis, in rats. METHODS: + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore. RESULTS: NPs also normalized the liver and intestinal histological changes. CONCLUSIONS: NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation.
Topics & Concepts
Carbon tetrachlorideFatty liverInternal medicineAlcoholic liver diseaseOxidative stressMalondialdehydeGlutathioneCCL4AntioxidantLiver injuryMedicineEndocrinologyChemistryGastroenterologyCirrhosisBiochemistryDiseaseOrganic chemistryEnzymeDrug-Induced Hepatotoxicity and ProtectionLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation