Direct Alkylation of Deoxyguanosine by Azaserine Leads to <i>O</i>⁶-Carboxymethyldeoxyguanosine

Abstract

-MedG in a human cell line exposed to l-azaserine and found maximal adduct levels after 48 h. The findings of this work elucidate the chemical basis of how l-azaserine reacts with deoxyguanosine and support its use as a chemical probe for N-nitroso compound exposure in carcinogenesis research, particularly concerning the identification of pathways and factors that promote adduct formation.

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