Manganese-Catalyzed N–F Bond Activation for Hydroamination and Carboamination of Alkenes
Yun‐Xing Ji, Jinxia Li, Chunmin Li, Shuanglin Qu, Bo Zhang
Abstract
A visible-light-promoted method for generating amidyl radicals from N-fluorosulfonamides via a manganese-catalyzed N–F bond activation strategy is reported. This protocol employs a simple manganese complex, Mn2(CO)10, as the precatalyst and a cheap silane, (MeO)3SiH, as both the hydrogen-atom donor and the F-atom acceptor, enabling intramolecular/intermolecular hydroaminations of alkenes, two-component carboamination of alkenes, and even three-component carboamination of alkenes. A wide range of valuable aliphatic sulfonamides can be readily prepared using these practical reactions.
Topics & Concepts
HydroaminationChemistryManganeseIntramolecular forceCatalysisIntermolecular forceSilaneRadicalAtom (system on chip)Medicinal chemistryMoleculePhotochemistryOrganic chemistryComputer scienceEmbedded systemCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques