IR-808 loaded nanoethosomes for aggregation-enhanced synergistic transdermal photodynamic/photothermal treatment of hypertrophic scars
Zhixi Yu, Xinxian Meng, Shunuo Zhang, Xiaodian Wang, Yunsheng Chen, Peiru Min, Zheng Zhang, Yixin Zhang
Abstract
transdermal delivery studies reveal that the IR-808-ES efficiently delivers IR-808 into HSFs in the HS tissue. Systematic assessments in the rabbit ear HS models demonstrate that the enhanced PDT/PTT performance of the IR-808-ES has remarkable therapeutic effects on improving the HS appearance, promoting HSF apoptosis and remodeling collagen fibers. Therefore, the IR-808-ES integrates both the transdermal delivery ability and the aggregation-enhanced PDT/PTT effect, and these features endow the IR-808-ES with significant potential as a novel nanophotosensitizer for the transdermal phototherapy of HSs in the clinical field.
Topics & Concepts
TransdermalPhotodynamic therapyChemistryPhotosensitizerIn vivoCyaninePhotothermal therapyApoptosisIn vitroPharmacologyBiophysicsBiochemistryNanotechnologyMedicineMaterials scienceBiologyFluorescenceBiotechnologyPhysicsOrganic chemistryQuantum mechanicsDermatologic Treatments and ResearchLaser Applications in Dentistry and MedicinePhotodynamic Therapy Research Studies