Acyldifluoromethylation Enabled by NHC-Photoredox Cocatalysis
Bei Zhang, Jian Wang
Abstract
With the continued interest in the properties of the difluoromethyl (CF2H) group, small molecules with alkyl-CF2H motifs have gained increasing attention. However, concise and efficient synthetic protocols to achieve these structures are still urgently needed. Herein, we report a new acyldifluoromethylation of inert alkenes via a synergistic NHC-photoredox catalysis featuring broad substrate scope and good functional group tolerance.
Topics & Concepts
ChemistryPhotoredox catalysisFunctional groupAlkylScope (computer science)Substrate (aquarium)Combinatorial chemistryInertCatalysisOrganic chemistryPhotocatalysisComputer scienceOceanographyGeologyPolymerProgramming languageFluorine in Organic ChemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCarbon dioxide utilization in catalysis