Efficient synthesis of an apremilast precursor and chiral β-hydroxy sulfones <i>via</i> ketoreductase-catalyzed asymmetric reduction
Jiyang Guo, Xiao Gao, Qian Dong, Huibin Wang, Xian Jia, Wenhe Zhang, Bin Qin, Song You
Abstract
)-2a was performed by employing the crude enzyme of LfSDR1-V186A/E141I and BsGDH to afford the desired enantiomer with >99% conversion, 85.9% isolated yield and 99.2% ee. This study presents a biocatalytic strategy to synthesize chiral β-hydroxy sulfones.
Topics & Concepts
ChemistryEnantioselective synthesisEnantiomeric excessKetoneCatalysisSubstrate (aquarium)EnantiomerYield (engineering)AlcoholCombinatorial chemistryApremilastAsymmetric hydrogenationStereochemistryOrganic chemistryPathologyGeologyMetallurgyMaterials scienceMedicineDiseaseOceanographyPsoriatic arthritisEnzyme Catalysis and ImmobilizationElectrochemical sensors and biosensorsCyclopropane Reaction Mechanisms